Can I Upload Yseq Y Dna Results To Familytreedna

YSEQ Review Summary

YSEQ is a DNA testing company that offers a variety of tests for decoding the Y chromosome and other parts of the genome. Acquire more in our YSEQ review!

Summary

YSEQ uses multiple next-generation sequencing products to analyze DNA however they tend to be more expensive than competitors and the interface tin can be difficult to navigate.

This review is written with the intent to be as unbiased as possible. Even so, it represents the opinion of an private reviewer and is therefore subjective. Furthermore, at Nebula Genomics we seek to educate the public about the benefits of Whole Genome Sequencing. Data most our Whole Genome Sequencing DNA test is therefore incorporated into the review.

March 7, 2022

7 Facts from our YSEQ Review
YSEQ Introduction
How does YSEQ Work?
- Review of YSEQ Services: The Basics of SNPs, STRs, and Haplogroups
- Review of YSEQ Y Chromosome Haplogroups
- Review of YSEQ Y Chromosome STRs, SNPs, and Panels
- Review of YSEQ mtDNA tests
- Review of YSEQ Full Genome Sequencing
Review of YSEQ Results
Downloading Your YSEQ Data
Review of YSEQ Privacy
YSEQ in the News
Other YSEQ Reviews
Pros and Cons
- Pros
- Cons
Nebula Genomics
- Less Effort For Yous
- With Great Data Comes Peachy Responsibility
- More than Only Beginnings with Nebula Expand
- Nebula Genomics 30x Whole Genome Sequencing

Edited past Christina Swords, Ph.D.

vii Facts from our YSEQ Review

YSEQ location: Federal republic of germany
Services: multiple next-generation sequencing products (Y-chromosome Dna testing, mtDNA, and whole-genome sequencing)
Information download: raw Dna data download available
Reports: Custom sequencing products; no Deoxyribonucleic acid interpretation reports
Privacy: strict application of confidentiality but open to disclosing information with your permission or under other pressing circumstances
Cost:ranges from less $100 to over $1500
Alternatives:Nebula Genomics (the about affordable 30x Whole Genome Sequencing)

YSEQ Introduction

YSEQ is a direct-to-consumer genetic testing visitor that primarily offers Y chromosome sequencing tests and services.

In recent years, the company has expanded and now offers mitochondrial DNA (mtDNA) and autosomal DNA tests (whole genome sequencing). Based in Germany, YSEQ was established in 2013 by Thomas and Astrid Krahn, former Family Tree DNA employees.

With YSEQ, users have full power to determine the verbal regions of the Y chromosome or mtDNA they want to sequence. Truthful to the company's tagline, "YSEQ: Deoxyribonucleic acid Origins Project," it caters to users who desire to amend understand their ancestry.

While the company offers an impressive range of custom sequencing options, this offer does non include reports with Dna estimation. Instead, most users must use third-party services, such as YFull, to interpret their raw data.

How does YSEQ Piece of work?

Review of YSEQ Services: The Basics of SNPs, STRs, and Haplogroups

Single nucleotide polymorphisms, or SNPs, are differences in DNA sequences at a unmarried nucleotide level. For example, when Dna sequences from two individuals differ at a single point, it is called an SNP.

On the other mitt, short tandem repeats, or STRs, are a serial of repeated Dna sequences that differ between individuals. Identifying the number of repeats at specific areas of the genome tin create a "Deoxyribonucleic acid fingerprint". This genomic fingerprint may exist used to determine someone'due south genealogy.

Together, SNPs and STRs are markers that tin exist inherited. A combination of such markers is known as a haplotype. Different Y-DNA and mtDNA tests for different haplotypes may assign people to a specific "haplogroup". For example, while Y-DNA tests can tell us more nearly paternal origins, mtDNA tests tell the states about maternal lineages.

The services offered by YSEQ are based on testing STRs and SNPs found in the Y chromosome and in mitochondrial Dna. The test can reveal bequeathed origins and genes associated with common ancestors.

You tin choose from many fixed Y chromosome haplogroup panels and STR marker panels. In improver, in that location are custom haplogroup panels and a nigh-endless number of custom SNPs.

Once users send their DNA to YSEQ, information technology is stored with the company in instance further analyses are required.

Prices for haplogroup panels — Prices for some of the haplogroup panels

Review of YSEQ Y Chromosome Haplogroups

At that place are 77 strict haplogroup panels and 179 custom haplogroup panels to choose from. Each i represents dissimilar ancestral origins.

YSEQ recommends that first-time users club the Tiptop Level Orientation Panel, which costs $159 and covers all the haplogroups. In this panel, YSEQ does multiple rounds of testing to decide your exact position in the Y chromosome ancestral tree.

It get-go determines whether you belong to the M169 or M9 category. Once this data is available, it works downwardly the tree to determine your super-clade. Each super-clade corresponds to different ancestral origins. For example, Haplogroup D-M174 is found in E Asia and the Andaman Islands.

The other 76 defined haplogroup panels are more specific, and cost between $88 and $99. Again, previous results from other tests can help users understand which specific haplogroup panel they would similar to gild.

For example, the Q Superclade Panel is for users who have other STR tests that bespeak them in this direction. YSEQ will test the users for defining markers in this console and so piece of work its way down the bequeathed tree.

In addition to the 77 defined haplogroup panels, YSEQ also offers 179 custom panels that piece of work similarly to family finders offered past other Deoxyribonucleic acid testing services.

These panels are highly specific and more expensive ($89 – $509). For case, the E1a1-Z31503 Phelps Panel is recommended for the "Phelps" surname origin. Similarly, the E1b-L1019 Goodrich Panel is for people named Goodrich. YSEQ is a good choice for genetic genealogists interested in such genographic projects.

If y'all are specially interested in genographic projects related to the British Isles, y'all should also check out Living Dna.

Review of YSEQ Y Chromosome STRs, SNPs, and Panels

YSEQ offers 9 combined STR panels ($25-$99), 125 specific STRs ($9.95-$15), and 131,611 SNPs ($one each) to choose from. If a SNP examination is non available, users tin put in a special request. Since each SNP corresponds to a dissimilar haplogroup, users tin can create their custom haplogroup console for testing.

All the same, this level of customizable testing requires a certain corporeality of prior knowledge and research. Users need to know their specific family history, have preliminary tests, and know the verbal haplogroup they desire to further investigate.

Review of YSEQ mtDNA tests

YSEQ offers 4 YSEQ mtDNA tests. Two YSEQ tests are for the mitochondrial hyper-variable region 1 (HPV1, $25) and region 2 (HPV2, $25). Users can too test their entire mitochondrial DNA ($145) or upgrade from HPV1 or HPV2 to the full mitochondrial Dna ($115).

There are also 30 additional mtDNA custom panels respective to specific regions of the mitochondrial Deoxyribonucleic acid ($xv-$60).

Review of YSEQ Full Genome Sequencing

YSEQ offers three levels of full genome sequencing, specifically for genealogy researchers. Once the YSEQ team receives the sample, it measures the DNA concentration and conducts quality control. It then sends it off for sequencing on a NovaSeq 6000 platform. Finally, from the raw DNA FASTQ files, information technology annotates all Y chromosome SNPs and provides mtDNA haplogroups.

Whole Genome Sequence 45 GBases: $579, Provides 15x coverage
Whole Genome Sequence 90 Gbases: $929, Provides 30x coverage
Whole Genome Sequence 150 Gbases: $1559, Provides 50x coverage

YSEQ conducts no medical or wellness analysis of the Dna information.

Review of YSEQ Results

Although YSEQ does not exercise whatever Dna assay or interpretation, users tin see whether they examination positive or negative for the reported haplogroups. Users also get a table to run across if they are ancestral (negative) or derived (positive) for SNPs.

YSEQ provides users with outcome pages for whole-genome sequencing that include a listing of SNPs found in the data with their ancestral states.

Users tin consign their data to third-political party websites (such as YFull) if they want farther analysis.

Downloading Your YSEQ Data

Customers can download their whole-genome sequencing data or go it mailed on a micro SD card. Still, YSEQ does non provide information about downloading the Y chromosome or mtDNA data and does not specify data formats.

Review of YSEQ Privacy

Once users send their Dna to YSEQ, it is stored and processed in Houston, Texas, in case further assay are required. When users send a sample and apply for the service, they automatically consent to the utilize of their information for internal inquiry and evolution.

The statement mentions a consent form that users sign for specific services. If at that place is no consent form for a particular service, the Privacy Policy stands.

YSEQ takes all responsibleness for keeping personal information private. However, it makes "enough full general information public to allow [YSEQ] to build a DNA database library usable for genealogical purposes."

With user consent, this information can be used for biological inquiry purposes. Your information will be anonymized unless explicitly requested past YSEQ. Users can contact Thomas Krahn and Astrid Krahn on the website.

YSEQ in the News

As a Deoxyribonucleic acid testing company specializing in bequeathed genetics and genealogy, YSEQ has not been particularly featured in the news. Here are a few articles, featured in Italian news websites:

"Gli abitanti di Sassalbo? Origini dal Mar Caspio". ("The inhabitants of Sassalbo? Origins from the Caspian Sea")
"Dal Medioevo ai giorni nostri: ho ricostruito l'albero genealogico dei Donadoni". ("From the Centre Ages to the present day: I rebuilt the Donadoni family tree")

Other YSEQ Reviews

The visitor does not accept many third party reviews online. However, there are near 250 customer generated reviews on its website. The ratings range from i to v stars. The customers who gave lower reviews annotation the long wait times. Higher reviewers shared interesting results and many noted that they confirmed suspected origins.

Pros and Cons

Pros

An incredible number of options for Y chromosome Deoxyribonucleic acid testing, with lots of room for customization
YSEQ makes information technology easy to narrow down the user's ancestry, with many different tests to do information technology
Total genome sequencing is available as an selection at very high coverage (50x)
Users can asking their own SNPs and STRs

Cons

Options are not equally extensive for mtDNA or total genome sequencing
Costs can pile upwardly as more follow-up tests are done on the same data
Users demand to practise their own research to interpret the data or pay actress money to third party Deoxyribonucleic acid analysis tools
Very expensive full genome sequencing
The website is difficult to navigate

Nebula Genomics

Nebula Genomics is dissimilar from YSEQ and other genetic testing companies because information technology focuses on providing extensive data analysis. This information assay can extend to the unabridged genome instead of just one or two regions of a chromosome.

We want you to accept the best feel on our website. With full access to genome exploration tools, you lot tin analyze your genetic information at any time without fearing hidden fees or costs. Unlike other companies, we utilise the newest research to regularly update your genetic reports. Furthermore, our reports comprise much more than just genetic ancestry.

Less Effort For You

Whether it'southward ancestry or health, we volition practice the research for you. Our intuitive interface allows you to unlock and understand your Dna information with minimal effort.

With Keen Data Comes Peachy Responsibility

At Nebula Genomics, nosotros understand and value your privacy higher up everything else. Ownership and control over your data are solely in your hands. If you choose to share your information with researchers, y'all can cull to be compensated.

Your data is stored on secure servers and is e'er encrypted. You can read more about the importance of DNA privacy.

More than Just Ancestry with Nebula Expand

Already have DNA data from other companies? You can upload information technology to receive a Nebula Genomics expanded written report. Our reports provide more information than other genetic companies, which use Deoxyribonucleic acid genotyping methods based on microarrays. Nosotros can fill up in the blanks using our advanced statistical models, called imputation.

Instead of having limited and static reports for individual genetic traits, our reports are updated regularly. You have immediate access to hundreds of traits in the Nebula Research Library with no subconscious fees.

Nebula Genomics 30x Whole Genome Sequencing

Our goal has ever been to put the ability in your hands.

The DNA testing methods used by other companies but provide data from a portion of your genome. This data may often be from just 1 chromosome.

This means that you may miss out on valuable data. With our 30x Whole Genome Sequencing service, we read 100% of your DNA. That is x,000 times more data, which we utilise to give yous an extensive report.

Picking the all-time place for your DNA examination is a very important determination. To make the conclusion a chip easier, here is a comparing of YSEQ, 23andMe, AncestryDNA, and Nebula Genomics.

	YSEQ	23andMe	AncestryDNA	Nebula Genomics
Deoxyribonucleic acid testing method	Y-chromosome sequencing, mtDNA sequencing, whole-genome sequencing (15x-50x coverage)	Genotyping	Genotyping	Whole Genome Sequencing (30x coverage)
DNA reports	Not provided	One total study	One full report	An extended study that is updated regularly
Y-DNA, mtDNA, and Ancestry Reporting	Yes, but you lot have to purchase mtDNA and Y Deoxyribonucleic acid separately. Users demand to practise their ain enquiry.	Yeah	Yes	Deep ancestry reporting with a full Y chromosome and mtDNA sequencing with results from FTDNA
Information ownership	Unclear whom the data belongs to	Unclear. The customer can have their saliva destroyed	Unclear. The customer tin can delete/destroy Dna and data	Your information permanently belongs to you
Focus on privacy	Yes	No	No	Yes (You tin learn more on our website)
Security applied science used	Unclear	Standard security protocols like SSL	Standard security protocols like SSL	Blockchain, privacy-preserving computing
Data upload options	Yeah, with a fee	No	No	Yep. Imputation enables an expanded report
Free updates based on new inquiry	No	No	No	At that place are weekly updates to the report (learn more)
Tools to explore data	None	Limited	Express	Aye (acquire more than)
Data access	Data tin can be downloaded, but the format is unclear	Yes (23andMe format file)	Yes (AncestryDNA format file)	Yes (FASTQ, BAM, and VCF files)
Cost	Varies depending on individual needs. Can be as high as $1559	$99 or $199	$99 or $308	$0, $99, $299

YSEQ vs 23andMe vs Ancestry vs Nebula Genomics

Check out more of the blog to acquire more than nearly the importance of sequencing Y-DNA and mtDNA and paternity testing.

Interested in whole genome sequencing? You tin check out these other products:

24Genetics (whole genome sequencing)
Color (low coverage whole genome sequencing available)
Dante Labs (30x whole genome sequencing, nearly reports are available at an boosted cost)
Full Genomes (options to upload data or exam for a comprehensive study)
Mapmygenome (but available in Bharat)
PerkinElmer Genomics (WES, WGS, newborn screening, and more)
Sequencing.com (whole genome sequencing)
Veritas Genetics (30x whole genome sequencing and advanced diagnostics)

Or would you lot similar to contribute to genomic research but be compensated? Check our our Luna DNA review!

Did you like our YSEQ review? You can read more reviews on our blog, including YFull that offers a similar product, and check out our complete guide to the best DNA test kit and other home tests.